MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer.Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

MacroGenics is a bold, highly engaged, and diverse team driven by a passion for improving the lives of patients through innovative science. We are committed to an inclusive workplace built on trust and respect. We value and nurture strong connections with one another and foster collaborative relationships. We empower our people and drive personal accountability. We encourage curiosity and embrace our entrepreneurial spirit. We celebrate our successes and create a learning environment where all employees can thrive!

Summary of Position

The intern will be developing a new, highly efficient molecular technique to create mutations in plasmids for the purpose of antibody engineering. Current methods to construct large synthetic antibody libraries are hindered by low transformation efficiency (PCR-digestion-ligation method), low recombination rate (Kunkel method) or a multi-step process with limited application (Pfunkel and Kunkel+RCA), thus a new method is needed that can easily insert mutations with high recombination rate. The method should be scalable to generate large quantities of mutagenic DNA with high transformation efficiency for creating a large synthetic antibody library.

Responsibilities and Job Duties

• Conduct experiments of molecular biology to identify conditions/methods to quickly create mutations in plasmids.
• Apply bioinformatic tools to analyze the mutation efficiency and evaluate the quality of the mutant library created by the new molecular technique.
• Perform biopanning experiments to evaluate the quality of the mutant library.

Minimum Qualifications

Education, Certifications & Experience

• Rising Senior/Master/PhD student working towards a degree in life science (Biology, Molecular & Cell Biology, or Biochemistry).
• Minimum GPA of 3.5 (Undergraduate)
• Extensive experiences in molecular biology (e.g., PCR and molecular cloning)

Knowledge, Skills and Abilities

• Strong skills in molecular biology
• Basic knowledge of protein/antibody engineering

Preferred Qualifications

• Understanding or experiences in bioinformatic analysis of next generation sequencing (NGS)

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email info@macrogenics.com or call (301) 354-3566 and/or 711 for TTD/TTY service.

Equal Opportunity Employer/Veterans/Disabled

We do not accept non-solicited resumes or candidate submittals from search/recruiting agencies.